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Related Experiment Video

Updated: Jun 14, 2026

Three Strategies to Induce Neurotrophic Keratitis and Nerve Regeneration in Murine Cornea
06:10

Three Strategies to Induce Neurotrophic Keratitis and Nerve Regeneration in Murine Cornea

Published on: December 8, 2023

Current Concepts in Corneal Neurotization.

Christopher Ashton1, Gregory H Borschel2, Kamiar Mireskandari1

  • 1From the Department of Ophthalmology and Vision Sciences (C.A., K.M., A.A.), The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Ophthalmology and Vision Sciences (C.A., K.M., A.A.), University of Toronto, Toronto, Ontario, Canada.

American Journal of Ophthalmology
|June 12, 2026
PubMed
Summary

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Cornea·2026

Neurotrophic keratopathy (NK) causes corneal nerve damage. Corneal neurotization (CN) restores corneal nerves, improving eye surface health and vision.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Regenerative Medicine

Background:

  • Neurotrophic keratopathy (NK) is caused by trigeminal nerve damage to the cornea.
  • This nerve loss disrupts corneal healing, tear film stability, and overall ocular surface health.
  • Current treatments manage NK symptoms but do not restore corneal sensation.

Purpose of the Study:

  • To evaluate corneal neurotization (CN) as a treatment for NK.
  • To assess the potential of CN to restore corneal innervation and improve ocular surface homeostasis.
  • To determine if CN can lead to visual rehabilitation in patients with NK.

Main Methods:

  • Surgical transfer of healthy donor nerve axons to the cornea.
  • Directly addressing the deficit of afferent innervation in the anesthetic cornea.

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Corneal Sensitivity Testing Procedure for Ophthalmologic and Optometric Patients
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Corneal Sensitivity Testing Procedure for Ophthalmologic and Optometric Patients

Published on: August 2, 2024

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Last Updated: Jun 14, 2026

Three Strategies to Induce Neurotrophic Keratitis and Nerve Regeneration in Murine Cornea
06:10

Three Strategies to Induce Neurotrophic Keratitis and Nerve Regeneration in Murine Cornea

Published on: December 8, 2023

Corneal Sensitivity Testing Procedure for Ophthalmologic and Optometric Patients
04:00

Corneal Sensitivity Testing Procedure for Ophthalmologic and Optometric Patients

Published on: August 2, 2024

  • Monitoring corneal epithelial integrity, tear film regulation, and sensory function.

    • Main Results:

    • Successful re-establishment of afferent innervation to the cornea.
    • Restoration of corneal epithelial maintenance and ocular surface homeostasis.
    • Evidence of improved visual function and rehabilitation.

    Conclusions:

    • Corneal neurotization is a promising therapeutic strategy for neurotrophic keratopathy.
    • CN effectively restores corneal sensory function, addressing the root cause of NK.
    • This approach offers a pathway for significant visual improvement in affected patients.