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Related Concept Videos

Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...

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Updated: Jun 14, 2026

A Minimally Invasive Model of Aortic Stenosis in Swine
06:51

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Published on: October 20, 2023

Aortic Stenosis Progression: Lessons from Multimodality Imaging.

Renuka Jain1, Ratnasari Padang2, Alexander Postalian3

  • 1Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's Medical Centers, Milwaukee, Wisconsin USA; Department of Cardiovascular Medicine, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina USA.

Mayo Clinic Proceedings
|June 12, 2026
PubMed
Summary
This summary is machine-generated.

Calcific aortic stenosis, common in older adults, is a metabolic process. Multimodality imaging helps assess disease severity and may guide future treatments to halt its progression.

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Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging

Published on: January 10, 2025

Area of Science:

  • Cardiovascular Medicine
  • Medical Imaging
  • Geriatrics

Background:

  • Calcific aortic stenosis is a prevalent condition in aging populations, leading to substantial morbidity and mortality.
  • The progression from a sclerotic aortic valve to severe aortic stenosis is an active metabolic process involving complex signaling pathways.

Purpose of the Study:

  • To review the clinical utility of various imaging modalities in assessing aortic stenosis.
  • To highlight how imaging can quantify disease severity and metabolic activity.
  • To identify imaging checkpoints for research trials targeting disease progression.

Main Methods:

  • Review of current literature on multimodality imaging for aortic stenosis.
  • Description of echocardiography, cardiac magnetic resonance imaging, cardiac computed tomography, and nuclear imaging applications.
  • Emphasis on assessing aortic valve calcification and metabolic activity.

Main Results:

  • Multimodality imaging effectively assesses aortic valve calcification and metabolic activity.
  • Imaging techniques can quantify the severity of aortic stenosis.
  • Echocardiography, CMR, CCT, and nuclear imaging offer distinct advantages in assessment.

Conclusions:

  • Multimodality imaging is crucial for evaluating aortic stenosis severity and metabolic activity.
  • Imaging findings can guide clinical decisions and patient management.
  • These imaging checkpoints represent potential targets for therapeutic interventions to slow disease progression.