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Updated: Jun 14, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
Published on: August 8, 2019
Chronobiomaterials for circadian-aligned brain therapeutics
Shubham Garg1, Burgundy Walters2, Diego C Fernandez3
1Division of Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Abstract:
Circadian rhythms are endogenous ~24 h oscillations that regulate daily changes in neural activity, metabolism, and behavior. Disruption of circadian rhythms is a hallmark of neurological and psychiatric disorders, yet most brain-directed therapies use fixed dosing schedules that do not account for time-of-day variations in drug efficacy and toxicity. Recent advances in bioengineering have led to the development of chronobiomaterials-including nanoparticles, exosomes, hydrogels, cell-based systems, and bioelectronic interfaces-that enable programmable and temporally precise control of therapeutic delivery. Here, we describe the multiscale organization of cellular and molecular circadian clocks in the brain, review chronobiomaterial platforms designed to modulate circadian phase, amplitude, and period, and discuss AI-enabled closed-loop approaches for personalized chronotherapy.
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