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Updated: Jun 14, 2026

Applying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits
08:27

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Published on: September 27, 2019

Implementing an accurate method of standard addition (MSA) using the EZMSA Excel or R tool.

Jocelyn V Abonamah1,2, Brigitte Desharnais1,3,4, Étienne Lebrun1,3,4

  • 1These authors contributed equally to the manuscript and are named in alphabetical order.

Journal of Analytical Toxicology
|June 12, 2026
PubMed
Summary
This summary is machine-generated.

The EZMSA tool simplifies accurate quantification using the method of standard addition (MSA) by optimizing calculations. This user-friendly software, available in Excel and R, removes mathematical barriers for toxicologists, enhancing analytical accuracy.

Keywords:
Method of standard additioncalibrationmeasurement uncertaintyquantificationweighting

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Area of Science:

  • Analytical Chemistry
  • Forensic Toxicology

Background:

  • The Method of Standard Addition (MSA) is a quantification technique.
  • Optimized MSA calculations improve accuracy but require advanced mathematical and programming skills, hindering widespread adoption.

Purpose of the Study:

  • To develop a user-friendly tool, EZMSA, for simplified and accurate MSA calculations.
  • To overcome the mathematical barriers hindering the dissemination of best MSA practices.

Main Methods:

  • Developed EZMSA as an Excel spreadsheet and R application (online/local).
  • EZMSA performs optimized MSA calculations, including spiked concentrations and calibration models.
  • R application generates customized reports (PDF, DOCX, HTML).

Main Results:

  • EZMSA platforms were validated using diverse datasets.
  • Demonstrated EZMSA's utility for quantifying alprazolam and phenazolam in blood samples.
  • The tool successfully simplifies complex MSA procedures.

Conclusions:

  • EZMSA effectively removes mathematical barriers for accurate MSA implementation.
  • The tool enhances analytical confidence through user-friendly, optimized calculations.
  • EZMSA promotes wider adoption of best practices in forensic and analytical toxicology.