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Implementing an accurate method of standard addition using the EZMSA Excel or R tool
Jocelyn V Abonamah1, Brigitte Desharnais2,3, Étienne Lebrun2
1Toxicology Department, Cuyahoga County Medical Examiner's Office (CCMEO), Cleveland, OH 44106, United States.
Journal of Analytical Toxicology
|June 12, 2026
Summary
The EZMSA tool simplifies accurate quantification using the method of standard addition (MSA) by optimizing calculations. This user-friendly software, available in Excel and R, removes mathematical barriers for toxicologists, enhancing analytical accuracy.
Area of Science:
- Analytical Chemistry
- Forensic Toxicology
Background:
- The Method of Standard Addition (MSA) is a quantification technique.
- Optimized MSA calculations improve accuracy but require advanced mathematical and programming skills, hindering widespread adoption.
Purpose of the Study:
- To develop a user-friendly tool, EZMSA, for simplified and accurate MSA calculations.
- To overcome the mathematical barriers hindering the dissemination of best MSA practices.
Main Methods:
- Developed EZMSA as an Excel spreadsheet and R application (online/local).
- EZMSA performs optimized MSA calculations, including spiked concentrations and calibration models.
- R application generates customized reports (PDF, DOCX, HTML).
Main Results:
- EZMSA platforms were validated using diverse datasets.
- Demonstrated EZMSA's utility for quantifying alprazolam and phenazolam in blood samples.
- The tool successfully simplifies complex MSA procedures.
Conclusions:
- EZMSA effectively removes mathematical barriers for accurate MSA implementation.
- The tool enhances analytical confidence through user-friendly, optimized calculations.
- EZMSA promotes wider adoption of best practices in forensic and analytical toxicology.
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