Related Experiment Video
Updated: Jun 14, 2026
Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients
Published on: March 29, 2022
Operationalizing a minimal-metric school screening pathway: using non-cycloplegic spherical equivalent as a
Wensi Chen1, Feng Chen1, Li Xie1
1Department of Pediatric Ophthalmology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, No. 9 Jinsui Road, Guangzhou, 510623, China.
Background:
School-based myopia screening commonly relies on non-cycloplegic refraction because cycloplegic refraction is difficult to implement universally at scale. This study evaluated whether non-cycloplegic spherical equivalent (NC-SE) could serve as a low-burden first-stage triage metric to identify children who warrant cycloplegic assessment for possible hyperopia reserve insufficiency (HRI).
Methods:
This cross-sectional school-based study included 1,650 children aged 6-15 years from Zengcheng District, Guangzhou, China. All participants underwent non-cycloplegic autorefraction, UCVA assessment, and cycloplegic autorefraction. Cycloplegic spherical equivalent (Cyclo-SE) was used as the reference standard for defining HRI, cycloplegic myopia, and pseudomyopia. HRI was operationally defined as preserved UCVA with low cycloplegic hyperopic reserve: Cyclo-SE from 0 to + 1.25 D in children aged 6-8 years and from 0 to + 1.00 D in children aged 9-15 years. Diagnostic performance of NC-SE for identifying HRI was assessed using receiver operating characteristic (ROC) analysis.
Results:
The prevalence of HRI was 14.1%, 10.5%, and 3.9% in the 6-8, 9-11, and 12-15-year-old groups, respectively. Correlation between NC-SE and Cyclo-SE strengthened with age (Spearman's rho: 0.641, 0.675, and 0.813; all p < 0.001). For detecting HRI, NC-SE achieved an AUC of 0.661 (95% CI: 0.618-0.704). A pragmatic cutoff of -0.50 D yielded a sensitivity of 0.824 (95% CI: 0.765-0.870), specificity of 0.550 (95% CI: 0.524-0.575), PPV of 20.5% (95% CI: 17.9-23.4), and NPV of 95.7% (95% CI: 94.1-96.9). Among children with normal visual acuity, 24.1% had pseudomyopia.
Conclusion:
NC-SE may serve as a low-burden first-stage triage metric in school-based screening to identify children who warrant cycloplegic assessment for possible HRI. However, its moderate AUC and low PPV indicate that NC-SE should not be interpreted as a stand-alone diagnostic test. Cycloplegic refraction remains necessary for confirming hyperopic reserve status. Further longitudinal studies incorporating axial length, accommodative measurements, and external validation are needed to determine its prognostic value for incident myopia.
Clinical Trial Number:
Not applicable.
