Thematic structure of clinically oriented prefrontal function assessment and intervention research: a keyword network...

Area of Science:

• Neuroscience and Psychology
• Clinical Research

Background:

• The prefrontal cortex (PFC) is crucial for higher-order cognition, emotional regulation, and behavioral control.
• Existing research on PFC function assessment and intervention lacks clear thematic organization and structural interconnections.
• Mapping these relationships can identify research concentrations and gaps.

Purpose of the Study:

• To clarify the thematic organization and structural interconnections within clinically focused prefrontal cortex literature.
• To identify dominant research concentrations and underrepresented areas in PFC function studies.

Main Methods:

• A total of 1,301 articles published between 2014-2024 were retrieved from major databases.
• Keywords were extracted and standardized, with the top 52 terms analyzed using network analysis (NetMiner 4.0).
• Network indices (density, centrality) and cohesive subgroup analysis were performed to identify thematic clusters.

Main Results:

• The keyword network showed high connectivity (density=0.408, avg. distance=1.621).
• Key hubs included Cognition, Depressive disorders, Randomized controlled trial, Cognitive behavioural therapy, and Psychotherapy.
• Seven thematic clusters were identified, including cognitive rehabilitation, emotional regulation, digital self-management, and stress resilience.

Conclusions:

• The literature exhibits a strongly interconnected structure focused on clinical assessment and interventions for PFC function.
• Neuroimaging and neurophysiological methods were underrepresented, indicating a focus on clinical applications over direct neural measurement.
• This network analysis provides a systematic overview of current research trends and a foundation for future studies.