Related Experiment Video
Updated: Jun 14, 2026

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
Published on: July 24, 2018
Circadian gatekeepers of the gut-brain-immune axis: implications for neuroinflammation and neurodegeneration
Wai-Yin Cheng1,2, Po-Lam Chan3, Man-Ka Chan4
1Department of Food Science and Nutrition, Faculty of Science, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China. wai-yin-nano.cheng@polyu.edu.hk.
Abstract:
Circadian rhythms, primarily regulated by light-dark cycles, play a crucial role in maintaining physiological health, including metabolism and immune responses. Evidence shows that circadian rhythms are involved in modulating gut microbiota composition, peripheral and central immune systems, and neurodegenerative disease progression. Recent research has illuminated the complex interplay between circadian rhythms and the gut microbiota-immune-brain axis. This review examines the bidirectional relationship between circadian rhythms and gut microbiota, and explores how this interaction influences brain function through the gut-brain axis, with particular focus on neuroinflammation and neurodegeneration. We aim to provide novel insights that could inform therapeutic strategies to prevent or slow down the progression of neurodegenerative diseases through circadian rhythm modulation.
Related Concept Videos
Gut-Brain Axis
Circadian Rhythms and Gene Regulation
Circadian Rhythms and Gene Regulation
Dysbiosis of the Gut Microbiota
Inflammatory Bowel Disease III: Crohn's Disease
Physiology of Enteric Nervous System and Gut Health
