Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondria and polycystic ovary syndrome: The role of ferroptosis, inflammasomes, and endoplasmic reticulum stress.

International journal of biological sciences·2026
Same author

Metabolic maturity patterns in neonates: dissecting the interactive effects of gestational age and birth weight on metabolic profiles.

Frontiers in pediatrics·2026
Same author

Correction: Li et al. Cherry Polyphenol Extract Ameliorated Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice by Suppressing Wnt/β-Catenin Signaling Pathway. <i>Foods</i> 2022, <i>11</i>, 49.

Foods (Basel, Switzerland)·2026
Same author

Effect of transcranial alternating current stimulation on auditory verbal hallucinations in patients with treatment-resistant schizophrenia.

Schizophrenia research·2026
Same author

Does frozen embryo transfer improve pregnancy outcomes in patients with ovarian endometriosis? A retrospective cohort study.

Reproductive biomedicine online·2026
Same author

Identification of novel compound heterozygote variants in the PCCB gene in a fetus with undetectable fetal phenotype.

BMC medical genomics·2026
Same journal

The Case for Limiting the Number of Offspring per Gamete Donor: A Response to Pennings.

Andrology·2026
Same journal

Feminizing Therapy in People With Klinefelter Syndrome and Gender Incongruence: Considerations for Treatment Without Testosterone Blockers.

Andrology·2026
Same journal

Author Reply: Erectile Dysfunction, Anxiety, Perceived Stress, and Insomnia Are More Common Among Acquired Premature Ejaculation Patients in Contrast to Other Premature Ejaculation Syndromes.

Andrology·2026
Same journal

Clomiphene Citrate in off-Label Post-Cycle Therapy: Mechanisms, Efficacy and Diagnostic Challenges in Endocrine Recovery Following Anabolic Steroid Use.

Andrology·2026
Same journal

Machine Learning-Based Prediction of Sperm Retrieval Outcomes in Patients With Klinefelter Syndrome: A Multicenter Study With External Validation.

Andrology·2026
Same journal

Umbilical Cord Blood-Derived Extracellular Vesicles Enhance Neurovascular Regeneration and Improve Erectile Function in a Mouse Model of Bilateral Cavernous Nerve Injury.

Andrology·2026
See all related articles

Related Experiment Video

Updated: Jun 14, 2026

High-Resolution Respirometry to Assess Mitochondrial Function in Human Spermatozoa
08:32

High-Resolution Respirometry to Assess Mitochondrial Function in Human Spermatozoa

Published on: June 23, 2023

Metabolic Reprogramming in Male Infertility: Mechanistic Integration and Translational Perspectives From Mouse

Jinyue Rong1,2,3, Lina Wang4, Huiming Yan4

  • 1Center of Reproductive Medicine, Shengjing Hospital of China Medical University, Shenyang, China.

Andrology
|June 13, 2026
PubMed
Summary
This summary is machine-generated.

Male fertility relies on precise metabolic reprogramming during sperm development. Disruptions in energy pathways cause infertility, leading to new classifications and potential therapeutic targets.

Keywords:
epigenetic regulationmale infertilitymetabolic classificationmetabolic reprogrammingmitochondrial functionspermatogenesis

More Related Videos

Mouse Round Spermatid Injection
08:41

Mouse Round Spermatid Injection

Published on: January 26, 2024

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
05:55

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

Related Experiment Videos

Last Updated: Jun 14, 2026

High-Resolution Respirometry to Assess Mitochondrial Function in Human Spermatozoa
08:32

High-Resolution Respirometry to Assess Mitochondrial Function in Human Spermatozoa

Published on: June 23, 2023

Mouse Round Spermatid Injection
08:41

Mouse Round Spermatid Injection

Published on: January 26, 2024

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
05:55

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

Area of Science:

  • Reproductive Biology
  • Metabolic Biochemistry
  • Male Infertility Research

Background:

  • Spermatogenesis is an energy-intensive process requiring dynamic metabolic adaptations.
  • Metabolic reprogramming is crucial for successful germ cell development, involving shifts in energy substrate utilization.
  • Metabolic dysfunction, arising from dysregulation, leads to impaired spermatogenesis and male infertility.

Purpose of the Study:

  • To explore the role of metabolic reprogramming in spermatogenesis and male infertility.
  • To propose a metabolism-centered classification for idiopathic male infertility.
  • To discuss potential therapeutic strategies targeting metabolic pathways.

Main Methods:

  • Analysis of mouse models with single-cell omics and metabolic profiling.
  • Review of experimental and clinical studies on metabolic disorders and male infertility.
  • Integration of energy-sensing pathways, endocrine regulation, and epigenetic modifications.

Main Results:

  • Germ cell development involves stage-specific transitions from glycolysis to oxidative phosphorylation (OXPHOS) and other substrates.
  • Metabolic dysfunction is characterized by oxidative stress, mitochondrial impairment, and meiotic defects.
  • Systemic metabolic disorders and environmental factors exacerbate testicular metabolic imbalance, affecting sperm quality.

Conclusions:

  • Idiopathic male infertility can be stratified into subtypes based on metabolic dysregulation (e.g., impaired glycolysis, OXPHOS deficiency).
  • Targeting metabolic pathways offers translational potential for diagnostics and therapeutics.
  • Future research should integrate advanced imaging, organoid models, and metabolomic biomarkers for precision medicine.