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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

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Updated: Jun 16, 2026

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management
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Published on: March 28, 2025

Neuromodulation Techniques Alleviating Neuropathic Pain by Targeting Microglia: A Narrative Review.

Qinghua Mu1,2,3,4, Xiaojin Li2,3,4, Long Li2,3,4

  • 1Department of Pain, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan, 430022, China.

Pain and Therapy
|June 13, 2026
PubMed
Summary

Neuromodulation shows promise for neuropathic pain (NP) by targeting microglia, the brain's immune cells. This review explores how these techniques regulate microglial activation for potential NP relief.

Keywords:
MicrogliaNeuroinflammationNeuromodulationNeuropathic painPain modulation

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Rapid Isolation of Dorsal Root Ganglion Macrophages
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Published on: September 7, 2019

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Last Updated: Jun 16, 2026

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Published on: March 28, 2025

Rapid Isolation of Dorsal Root Ganglion Macrophages
07:22

Rapid Isolation of Dorsal Root Ganglion Macrophages

Published on: September 7, 2019

Area of Science:

  • Neuroscience
  • Immunology
  • Pain Management

Background:

  • Neuropathic pain (NP) pathogenesis is not fully understood, with limited treatment options.
  • Neuromodulation offers a promising, non-invasive approach for NP management.
  • Microglia activation is central to NP development and maintenance.

Purpose of the Study:

  • To review current evidence on microglia-targeted neuromodulation for NP.
  • To differentiate between preclinical and clinical findings in NP neuromodulation.
  • To provide a foundation for future research in NP treatment.

Main Methods:

  • Literature synthesis of preclinical and clinical studies.
  • Analysis of neuromodulation's impact on microglial activation states.
  • Review of indirect and direct mechanisms of neuromodulation on microglia.

Main Results:

  • Neuromodulation can modulate microglial activation via indirect and direct pathways.
  • Indirect mechanisms involve altering neuronal activity.
  • Direct mechanisms target microglia-specific properties like receptor expression.

Conclusions:

  • Neuromodulation strategies targeting microglia represent a significant advance in NP research.
  • Further research is needed to standardize therapeutic parameters for NP neuromodulation.
  • Understanding microglia-neuromodulation interactions is key for developing effective NP therapies.