Related Experiment Video
Updated: Jun 16, 2026
07:49
Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
Published on: June 2, 2022
Targeting the gut-brain axis: microbial interventions for neurological disorders
Yu-Yao Hao1, Zhen-Ao Zhao2,3,4, Li-Min Zhang2,3,4
1Institute of Microcirculation & Basic Medical College, Hebei North University, Diamond South Road 11, Zhangjiakou, Hebei, 075000, China. hyy010115@163.com.
Metabolic Brain Disease
|June 13, 2026
Summary
The gut microbiome influences neurological disorders via the gut-brain axis. Microbiota-targeted therapies show promise for managing conditions like traumatic brain injury, stroke, and epilepsy.
Area of Science:
- Neuroscience
- Microbiology
- Immunology
Background:
- Neurological disorders stem from complex genetic, environmental, immunological, and metabolic factors.
- These conditions cause significant disability and societal burden.
- Gut microbiota significantly impacts neurological disorder onset and progression via the gut-brain axis.
Purpose of the Study:
- To systematically review the role of gut microbiota in neurological disorders.
- To evaluate the therapeutic potential of microbiota-targeted interventions.
Main Methods:
- Systematic review of current evidence.
- Critical evaluation of interventions like fecal microbiota transplantation, ketogenic diets, and probiotics.
Main Results:
- Gut microbiota communicates bidirectionally with the central nervous system.
- This communication influences blood-brain barrier integrity, neuroinflammation, and neurotransmitter balance.
- Evidence links gut microbiota dysbiosis to traumatic brain injury, stroke, and epilepsy.
Conclusions:
- Gut microbiota is a key factor in neurological disease pathogenesis.
- Microbiota-targeted therapies offer innovative strategies for neurological disease prevention and management.
Related Concept Videos
01:22Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
01:21Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
01:18Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
01:18Functions of the Gut Microbiota
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
01:29Microorganisms in Medicine and Therapeutics
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
01:17Irritable Bowel Syndrome I: Introduction
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...