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Updated: Jun 16, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
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Don't Sweat It: Cannabinoid CB1 Receptors Reduce Sweating in a Mouse Model.

Natalia Murataeva1,2, Joseph Youkilis1, Yogith Rao1

  • 1Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, USA.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|June 13, 2026
PubMed
Summary

Cannabinoid CB1 receptors reduce sweating, according to a new study on mice. This finding suggests a potential link between cannabis use and altered sweating responses in humans.

Keywords:
CB1cannabinoidexocrinehyperhidrosissweating

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Area of Science:

  • Physiology
  • Neuroscience
  • Pharmacology

Background:

  • Exocrine glands, including sweat glands, are vital for physiological functions like thermoregulation.
  • Sweating disorders are prevalent and current therapies have limited efficacy.
  • The cannabinoid signaling system is implicated in regulating other exocrine functions, suggesting a similar role in sweating.

Purpose of the Study:

  • To investigate the role of the cannabinoid signaling system in regulating sweating.
  • To explore the specific involvement of cannabinoid receptors (CB1 and CB2) in sweat gland function.
  • To establish a reliable assay for measuring sweating in mice.

Main Methods:

  • Development and application of a galvanic skin response-based assay in awake, unanesthetized mice.
  • Administration of muscarinic agents (pilocarpine, glycopyrrolate) to validate the assay.
  • Testing of cannabinoid receptor agonists (CP55940, THC, CBD) and analysis in wild-type and knockout mice (CB1, CB2).
  • Immunohistochemical analysis to identify cannabinoid signaling components in mouse paw sweat glands.

Main Results:

  • The assay successfully measured sweating, validated by pilocarpine and glycopyrrolate responses.
  • Cannabinoid receptor agonist CP55940 significantly reduced sweating in wild-type and CB2 knockout mice, but not in CB1 knockout mice.
  • Tetrahydrocannabinol (THC) reduced sweating, while cannabidiol (CBD) had no significant effect.
  • Immunohistochemistry revealed CB1 receptors in periglandular cholinergic axons, NAPE-PLD in myoepithelial cells, and FAAH in acinar cells, indicating a local CB1/anandamide circuit.

Conclusions:

  • Cannabinoid CB1 receptors play a significant role in reducing sweating.
  • A local CB1/anandamide signaling pathway is present in mouse sweat glands.
  • These findings suggest a potential mechanism for altered sweating in cannabis users.