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Updated: Jun 16, 2026

Assays for the Degradation of Misfolded Proteins in Cells
10:56

Assays for the Degradation of Misfolded Proteins in Cells

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Role of the Proteasome System in Shaping Cellular Immunological Characteristics and Its Impact in Modulating the

Ejlal Abu-El-Rub1, Hana M Zegallai1,2, Ramada Khasawneh1

  • 1Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.

Cells, Tissues, Organs
|June 13, 2026
PubMed
Abstract

Keywords:
26S proteasomeAutoimmune diseasesBarth syndromeCancerImmune system biologyImmunodeficiency diseasesImmunoproteasomeMesenchymal stem cells

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In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
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Eukaryotic cells can degrade proteins through several pathways. One of the most important among these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
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In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
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Regulated Protein Degradation02:58

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It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
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