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Updated: Jun 16, 2026
Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
Published on: January 9, 2019
Histone methylation machinery in gliomas: From enzymatic mechanisms to inhibitor development
Xiaoran Wang1, Wenqi Liu2, Jie Sun2
1Pharmaceutical Laboratory, Department of Pharmacy, Linyi People's Hospital, Shandong Second Medical University, Linyi, China; School of Pharmacy, Shandong Second Medical University, Weifang, China.
Abstract:
Glioma is the most common primary malignant tumor of the central nervous system (CNS). Advances in molecular pathology have established a robust causal link between histone modifications and glioma genesis. In addition to prior findings, recent empirical evidence has unequivocally substantiated the intricate and close relationship between histone modifications and temozolomide (TMZ) resistance, thereby advancing our understanding in this field. This article systematically reviews the roles of histone methylation modifications in glioma pathogenesis and their implications for the mechanisms of therapeutic drug action. Moreover, the latest research advancements concerning histone methylation - related enzymes and their inhibitors in the diagnosis and treatment of glioma were elaborately described, highlighting their significant implications for the field. It is highly anticipated that this review will serve as a catalyst, offering a novel and insightful direction for the ongoing research endeavors, diagnostic approaches, and therapeutic strategies pertaining to glioma.
Insights
Histone methylation modifications are crucial in glioma development and resistance to temozolomide (TMZ). Understanding these epigenetic changes offers new diagnostic and therapeutic strategies for brain tumors.
Area of Science:
- Neuro-oncology
- Epigenetics
- Molecular Pathology
Background:
- Glioma is a common primary malignant central nervous system (CNS) tumor.
- Histone modifications are increasingly recognized as key drivers of glioma genesis.
- Recent evidence highlights the link between histone modifications and temozolomide (TMZ) resistance.
Purpose of the Study:
- To systematically review the role of histone methylation in glioma pathogenesis.
- To explore the implications of histone methylation in temozolomide (TMZ) resistance mechanisms.
- To summarize advancements in targeting histone methylation-related enzymes for glioma diagnosis and treatment.
Main Methods:
- Systematic literature review.
- Analysis of empirical evidence on histone methylation and glioma.
- Review of research on histone methylation-related enzymes and inhibitors.
Main Results:
- Histone methylation plays a significant role in glioma development.
- Histone modifications are closely associated with temozolomide (TMZ) resistance.
- Histone methylation-related enzymes and inhibitors show promise in glioma management.
Conclusions:
- Histone methylation is integral to glioma pathogenesis and therapeutic resistance.
- Targeting histone methylation pathways presents novel opportunities for glioma treatment.
- Further research into histone methylation offers new directions for glioma diagnosis and therapy.
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