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Related Concept Videos

Infertility in Females01:28

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Close Relationships and Culture01:29

Close Relationships and Culture

Culture shapes how people approach attraction, choose partners, and build long-term relationships. While some preferences in mate selection appear consistent across cultures, such as men valuing physical attractiveness and women emphasizing financial resources, cultural contexts influence how these preferences are expressed and prioritized. Marriage extends beyond romantic ideals in many societies and is deeply embedded in social, economic, and religious frameworks.The Role of Culture in Mate...
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Birth Control Methods01:22

Birth Control Methods

Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...

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Related Experiment Video

Updated: Jun 16, 2026

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection
06:11

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection

Published on: May 17, 2024

Delayed childbearing and its impact.

Vanessa Vergara1, Juan A García-Velasco1

  • 1IVIRMA Global Research Alliance, IVIRMA Madrid, Spain.

Reproductive Biomedicine Online
|June 13, 2026
PubMed
Summary
This summary is machine-generated.

Delayed childbearing impacts fertility due to reproductive ageing, affecting egg quality and increasing risks. Assisted reproductive technologies offer strategies to mitigate these effects for women undergoing fertility treatments.

Keywords:
Advanced maternal ageAneuploidyDelayed childbearingOocyte qualityOvarian reserve

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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
08:46

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

Related Experiment Videos

Last Updated: Jun 16, 2026

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection
06:11

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection

Published on: May 17, 2024

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
08:46

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

Area of Science:

  • Reproductive biology and endocrinology
  • Maternal-fetal medicine
  • Genetics and genomics

Background:

  • Delayed childbearing is a global trend with significant individual consequences.
  • Reproductive ageing involves decreased ovarian reserve and oocyte quality, driven by mitochondrial dysfunction and oxidative stress.
  • These age-related changes contribute to embryonic aneuploidy, impacting natural fertility, IVF success, and miscarriage rates.

Purpose of the Study:

  • To review the biological mechanisms of reproductive ageing and their impact on female fertility.
  • To discuss the role of assisted reproductive technologies in addressing age-related fertility decline.
  • To highlight the risks associated with advanced maternal age for pregnancy outcomes.

Main Methods:

  • Literature review of reproductive ageing, oocyte quality, and assisted reproductive technologies.
  • Analysis of mechanisms underlying oocyte ageing, including mitochondrial dysfunction and oxidative stress.
  • Examination of assisted reproductive technology strategies and pregnancy outcomes in advanced maternal age.

Main Results:

  • Oocyte ageing is characterized by mitochondrial dysfunction and oxidative stress, leading to aneuploidy and reduced fecundity.
  • Assisted reproductive technologies like preimplantation genetic testing and oocyte preservation can aid fertility.
  • Advanced maternal age increases risks for maternal, fetal, and neonatal complications.

Conclusions:

  • Reproductive ageing significantly impacts female fertility through oocyte quality decline and increased aneuploidy.
  • Assisted reproductive technologies provide options for managing age-related fertility challenges.
  • Awareness and management of risks associated with delayed childbearing are crucial for improved pregnancy outcomes.