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Caution in Interpreting In Vitro Studies of CYLD Variants

Agathe Hercent1, Dimitri Tchernitchko2

  • 1Department of genetics, Bichat Hospital (APHP), Reference Laboratory for the diagnosis of Birt Hogg Dube Syndrome, University of Paris Cité, France; INSERM U1149, Centre de Recherche sur l'Inflammation, University Paris Cite, France.

The Journal of Investigative Dermatology
|June 13, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
CylindromatosisGenotype-Phenotype correlationRNA sequencing

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In vitro Mutagenesis01:16

In vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

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