Related Experiment Video
Updated: Jun 16, 2026
In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)
Published on: August 1, 2025
Hepatic involvement as the initial manifestation of B-cell acute lymphoblastic leukemia in adults: A case series
S A Chávez-Sánchez1, A Bellido-Caparó1, C A García-Encinas2
1Servicio de Gastroenterología, Clínica San Felipe, Lima, Peru; Universidad Peruana Cayetano Heredia, Lima, Peru.
Introduction:
Hepatic involvement as an initial presentation of acute lymphoblastic leukemia (ALL) in adults is rare and may delay the diagnosis.
Material And Methods:
A case series of adult patients with confirmed B-cell ALL (B-ALL) and altered liver function tests at disease onset was conducted. Clinical, biochemical, imaging, and flow cytometry data were collected, ruling out infectious, autoimmune, and toxic etiologies.
Results:
Three men, 68, 36, and 38 years of age, presented with cholestasis and hepatosplenomegaly with no biliary tract dilation. Flow cytometry showed high percentages of B lymphoblasts. One patient died shortly after starting chemotherapy and the other two remain on active treatment.
Conclusion:
Hepatic infiltration due to ALL should be considered in the differential diagnosis of cholestasis with a normal biliary tract in adults.
