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Glue versus Laser Ablation in Mini-invasive Pilonidal sinus surgery-the GLAMP study: a study protocol for a
Karita Koskinen1,2, Hanna Koppatz3, Tuija Poussa4
1Faculty of Medicine, University of Helsinki, Helsinki, Finland. karita.koskinen@helsinki.fi.
Trials
|June 13, 2026
Summary
This study compares laser ablation and fibrin glue for pilonidal sinus disease (PSD) surgery. It evaluates healing rates, recurrence, and costs to determine the best mini-invasive treatment for PSD patients.
Area of Science:
- Surgical Innovation
- Minimally Invasive Procedures
- Clinical Trial Research
Background:
- Pilonidal sinus disease (PSD) is a chronic condition impacting the working-age population, causing significant morbidity and healthcare costs.
- Randomized studies on PSD surgical techniques, particularly newer mini-invasive methods, are limited.
- Existing comparative studies on laser ablation and fibrin glue for PSD often involve small patient numbers, hindering statistical significance.
Purpose of the Study:
- To compare the efficacy of two mini-invasive techniques for pilonidal sinus disease (PSD) surgery: laser ablation versus fibrin glue treatment.
- To evaluate short-term outcomes (healing rates) and long-term outcomes (recurrence rates) of these two minimally invasive PSD treatments.
- To assess the cost-effectiveness of laser ablation compared to fibrin glue in PSD management.
Main Methods:
- A randomized, prospective, multicenter, non-blinded superiority study comparing laser ablation and fibrin glue in PSD patients.
- Patients were randomly assigned to either laser ablation or fibrin glue treatment post-suitability assessment by the surgeon.
- Outcomes included healing rates, recurrence rates, quality of life (RAND-36/SF-36), and patient-reported recovery and discomfort at 2 months post-surgery.
Main Results:
- This section is not available in the provided abstract.
- Further analysis will determine statistical significance between laser ablation and fibrin glue for PSD treatment.
- Cost analysis will be conducted to compare the economic impact of both procedures.
Conclusions:
- There is a need for more high-quality randomized trials to compare surgical methods for pilonidal sinus disease (PSD).
- This study aims to provide statistically significant comparisons between laser ablation and fibrin glue for PSD.
- The findings will elucidate short- and long-term differences in recovery and healing between these minimally invasive PSD surgical techniques.
