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Published on: March 10, 2023
The Evolving Role of Surgery in Hepatocellular Carcinoma Management: From Resection to Multidisciplinary Strategy
Takehiro Okabayashi1, Motoyasu Tabuchi1, Teppei Tokumaru1
1Department of Gastroenterological Surgery, Kochi Health Sciences Center, Kochi City, Kochi, Japan.
Background:
Hepatocellular carcinoma (HCC) frequently develops in the setting of chronic liver disease, making its management uniquely complex and historically centered on surgery.
Recent Findings:
Advances in locoregional therapies, molecular targeted agents, and immune checkpoint inhibitors have profoundly transformed treatment algorithms. Immunotherapy-based combinations achieve deep and durable responses, enabling downstaging, conversion surgery, and perioperative strategies previously considered unfeasible.
Conclusion:
In the contemporary era, surgeons serve not only as technical operators but as strategic leaders within multidisciplinary teams, integrating evolving systemic and local therapies to achieve durable oncologic outcomes.
