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Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...

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Related Experiment Video

Updated: Jun 16, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
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Dynamic Network Reconfiguration of Brain Function During Exposure to Aversive Stimuli.

Zhoukang Wu1, Min Wang2, Lei Guo3

  • 1Department of Metabolic & Bariatric Surgery, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, Shanghai, China.

Obesity (Silver Spring, Md.)
|June 14, 2026
PubMed
Summary

Individuals with obesity exhibit altered brain network dynamics when processing aversive food cues. This impaired visual-DAN-SUB network integration is linked to eating disorder symptoms, suggesting a neurobiological basis for interventions.

Keywords:
aversioncognitive impulsivitydynamic brain networksneurotransmitter receptorobesity

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Area of Science:

  • Neuroscience
  • Public Health
  • Psychiatry

Background:

  • Obesity is a major public health issue linked to abnormal responses to food stimuli.
  • Understanding brain network dynamics in aversion processing is crucial for obesity pathophysiology.

Purpose of the Study:

  • To investigate dynamic brain network alterations during aversion processing in individuals with obesity.
  • To explore the clinical implications of these network changes in relation to eating disorders.

Main Methods:

  • fMRI was used to record brain activity in 30 participants with obesity and 35 healthy controls.
  • Dynamic network analysis and Granger causality were applied to assess neural circuit alterations and effective connectivity.

Main Results:

  • Participants with obesity showed reduced integration between visual (VN), dorsal attention (DAN), and subcortical (SUB) networks when viewing spoiled food.
  • DAN-SUB integration correlated with body image distress and craving, and moderated the link between impulsivity and eating disorders.
  • A dominant indirect pathway with differential neurotransmitter receptor associations was identified.

Conclusions:

  • Dynamic VN-DAN-SUB interactions are key in aversion processing, with impaired coordination in obesity.
  • Inefficient network coordination may hinder aversive food stimulus regulation, supporting the emotion regulation deficit hypothesis.
  • Findings offer a neurobiological basis for developing novel interventions for obesity and related eating disorders.