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Genomic Confirmation of HLA-C*01:155, by Next Generation Sequencing.

Jarret Merschman¹, Rachel Barnes¹, Justin Kreuter¹

¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

|June 14, 2026

Summary

The human leukocyte antigen (HLA) C*01:155 allele is identified by a specific genetic alteration. This single nucleotide substitution occurs in codon 225 within exon 4 of the HLA-C gene.

Keywords:

HLA‐C*01:155 allele confirmation histocompatibility immunogenetics next generation sequencing

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Area of Science:

Immunogenetics
Molecular Biology
Human Leukocyte Antigen (HLA) System

Background:

The Human Leukocyte Antigen (HLA) complex plays a critical role in immune response and transplantation.
Specific HLA alleles are associated with diverse immune functions and disease susceptibilities.
Detailed characterization of novel HLA alleles is essential for understanding immune diversity.

Purpose of the Study:

To describe the molecular characteristics of the newly identified HLA-C*01:155 allele.
To provide precise genetic information for this specific HLA allele.

Main Methods:

Sequence analysis of the HLA-C gene.
Identification of nucleotide variations.
Comparison with known HLA allele sequences.

Main Results:

The HLA-C*01:155 allele is defined by a single nucleotide substitution.
This substitution is located at codon 225 in exon 4 of the HLA-C gene.

Conclusions:

The genetic signature of HLA-C*01:155 has been precisely identified.
This characterization contributes to the growing database of HLA allele variations.
Understanding such variations is crucial for HLA typing and immunological studies.