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Biochemical and High Throughput Microscopic Assessment of Fat Mass in Caenorhabditis Elegans
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Transcriptomic Analysis in the Liver of Two Rabbit Lines Divergently Selected for Intramuscular Fat Content.

Jesús Valdés-Hernández1, Agostina Zubiri-Gaitán1, Marina Martínez-Álvaro1

  • 1Institute for Animal Science and Technology, Universitat Politècnica de València, Valencia, Spain.

Animal Genetics
|June 14, 2026
PubMed
Summary
This summary is machine-generated.

Researchers identified key genes and transcription factors influencing intramuscular fat (IMF) deposition in rabbits. This study enhances understanding of liver-muscle communication for improving meat quality.

Keywords:
RNA sequencingdivergent selectionintramuscular fat selectionlipid metabolismliver transcriptomerabbits

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Published on: March 12, 2021

Area of Science:

  • Animal Genetics and Genomics
  • Meat Science and Quality
  • Molecular Biology

Background:

  • Intramuscular fat (IMF) content is crucial for meat quality and sensory attributes.
  • IMF is a complex, polygenic trait influenced by numerous genes.
  • Understanding the genetic basis of IMF deposition is vital for livestock improvement.

Purpose of the Study:

  • To identify differentially expressed genes (DEGs) associated with IMF deposition in rabbits.
  • To pinpoint key transcription factors (TFs) regulating IMF-related gene expression.
  • To elucidate the molecular mechanisms underlying liver-muscle crosstalk in IMF development.

Main Methods:

  • Divergent selection for high-IMF (H) and low-IMF (L) rabbit lines (9th generation).
  • 3' RNA sequencing to analyze liver gene expression in 48 rabbits (24 H, 24 L).
  • Gene regulatory network analysis to predict TF-target gene interactions.

Main Results:

  • Identified 263 DEGs between H and L lines, with over 30 linked to lipid metabolism and energy homeostasis.
  • Predicted 175 target genes for 11 DE TFs, highlighting ETV1, NR4A1, and IKZF3 as potential key regulators.
  • Functional analysis revealed enrichment of the PPAR signaling pathway and other lipid metabolism pathways.

Conclusions:

  • This study reveals novel DEGs and TFs involved in IMF deposition in rabbits.
  • Findings provide insights into the molecular mechanisms of liver-muscle communication influencing meat quality.
  • The identified genes and pathways offer targets for genetic improvement of rabbit meat quality.