Related Experiment Video
Updated: Jun 16, 2026
Multimodal Analysis of Microplastics in Drinking Water using a Silicon Nanomembrane Analysis Pipeline
Published on: June 13, 2025
Degradation reshapes the toxic identity of polylactic acid microplastics through MSR1-dependent immune decoding in
Xiaoqing Chen1, Yanhong Deng1, Xiyun Huang1
1Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou, 510515, China.
Background:
Biodegradable plastics are increasingly being used as a sustainable alternative, but their degradation in biological environments may produce transformation products with unexpected toxicological characteristics. These products generate a distribution pattern in the kidneys that differs from other organs, with the accumulation of low-molecular-weight polylactic acid microplastics (PLA MPs) being far higher than that of high-molecular-weight tissues.
Methods:
PLA is used as a representative bioplastic. We used polymeric and oligomeric MPs to simulate their original and partially degraded states. Mice were exposed to these MPs through repeated oral administration under controlled experimental exposure conditions for 28 consecutive days to study the accumulation and inflammatory damage caused by PLA oligomer and polymer MPs in the kidneys. In combination with in vitro transcriptomic analysis, we explored the potential mechanisms by which oligomers drive nephrotoxicity.
Results:
Exposure to PLA oligomer MPs results in significantly higher accumulation in the kidneys compared to PLA polymer MPs, and triggers more severe inflammatory damage. The mechanism is that renal macrophages preferentially phagocytose PLA oligomer MPs and decode them through macrophage scavenger receptor 1 (MSR1), activating phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) signaling and inducing chemokine ligand 2 (CCL2)-dependent macrophage recruitment, thereby establishing a self-amplifying inflammatory loop. Inhibiting MSR1 or PI3K/AKT effectively reduces oligomer-driven cytokine production, macrophage infiltration, and renal injury, narrowing the toxicity gap between oligomeric and polymeric PLA MPs in the kidneys.
Conclusions:
These findings reveal that biodegradation can heighten the inflammatory potential of MPs, and that distinct polymerization states of the same material elicit different immune interpretations. Our work provides mechanistic clarity on how degradability reshapes microplastic toxicity, underscoring the need to incorporate degradation-state profiling into the safety assessment of biodegradable MPs.
