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Published on: August 12, 2019
Fe(NO3)3·9H2O-Promoted Direct Deaminative Thiocyanation of Primary Amine
Xinyang Jiang1, Wu Zheng2, Yang Zhao1
1College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. China.
Abstract:
Herein, we report an Fe(NO3)3·9H2O-promoted direct deaminative thiocyanation reaction of primary amines. This protocol is compatible with aryl, heteroaryl, and benzyl primary amines, proceeding under mild reaction conditions with good tolerance for a wide range of functional groups. KSCN serves not only as a thiocyanation reagent but also as a reducing agent, thereby eliminating the need for an additional reducing agent in the reaction system. Thus, it provides a facile and efficient route to access thiocyanates. Furthermore, this method is also applicable to the synthesis of selenocyanates.
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