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Associations Between Admission C-Reactive Protein and In-Hospital Mortality Amongst Patients with Cardiogenic Shock.
Sierra Mendelsohn1, Alexander Ambrosini2, Israel Safiriyu2
1Department of Internal Medicine, Yale School of Medicine, New Haven, CT.
European Heart Journal. Acute Cardiovascular Care
|June 15, 2026
Summary
Elevated C-reactive protein (CRP) levels in patients with cardiogenic shock correlate with increased in-hospital mortality. This accessible biomarker can help assess risk and severity in these critically ill patients.
Area of Science:
- Cardiology
- Critical Care Medicine
- Biomarkers
Background:
- Systemic inflammation is linked to worse outcomes in cardiogenic shock.
- C-reactive protein (CRP) is an accessible inflammatory marker for risk stratification.
Purpose of the Study:
- To evaluate the association between admission C-reactive protein (CRP) levels and in-hospital mortality in patients with cardiogenic shock.
Main Methods:
- A multicentre database analysis included 26,525 adults with cardiogenic shock (2015-2023), excluding sepsis.
- C-reactive protein (CRP) levels were analyzed in tertiles using inverse probability weighting (IPW).
- Secondary outcomes included ICU/hospital length of stay and total cost.
Main Results:
- Higher C-reactive protein (CRP) tertiles were associated with increased in-hospital mortality (42.3% in tertile 3).
- Each 50-unit CRP increase correlated with a 19% higher mortality risk (OR 1.19).
- IPW showed significantly higher mortality risks in higher CRP tertiles; ICU and hospital stays increased, but total cost did not differ.
Conclusions:
- Elevated C-reactive protein (CRP) is a significant predictor of higher in-hospital mortality in cardiogenic shock patients.
- CRP serves as a valuable, readily available biomarker for assessing risk in cardiogenic shock.
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