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Identification of Hemolytic and Phospholipase Activity in Crude Extracts from Sea Anemones by Straightforward Bioassays
Published on: March 29, 2022
Chemical Constituents of the Deep-Sea-Derived Penicillium roseopurpureum and Their Anti-Inflammatory Activity
Zheng-Biao Zou1, Xiao-Wei Zhao1, Zi-Han Xu1
1Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China.
Abstract:
Marine natural products are well-recognized as potential resources to fill the pipeline of drug leads to enter the pharmaceutical industry. In the present study, one new γ-butyrolactone derivative (1), together with 20 known compounds (2-21), were isolated from an Penicillium roseopurpureum, isolated from sediments collected from the Atlantic. Compounds 2 and 3 were registered in SciFinder under CAS registry numbers 1823883-92-6 and 2386376-03-8, respectively. However, no characterization data, spectral information, or references are available for either compound. Their structures were determined by detailed analysis of the 1D and 2D NMR, HRESIMS, and NMR calculations with DP4+ probability analysis, as well as ORD calculations. The anti-neuroinflammatory effects of all isolates were assessed in lipopolysaccharide (LPS)-stimulated BV-2 microglial model. Remarkably, compound 13 exhibited notable anti-neuroinflammatory activity with IC50 values of 6.72 µM.
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