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Distinct Innate Immune Responses Following Inoculation With a Replicon mRNA COVID-19 Vaccine
Tetsuo Nakayama1, Takashi Ito1,2, Kazuhiko Katayama1
1Laboratory of Viral Infection, Ömura Satoshi Memorial Institute, Tokyo, Japan.
Abstract:
Innate immune responses trigger the development of adaptive immune responses through the production of cytokines. In the present study, we compared the cytokine production in mice inoculated with a novel replicon mRNA COVID-19 vaccine. Biphasic and prolonged IFN-γ production was observed after the first dose, and sustained production was observed after the second dose, whereas conventional mRNA vaccines induced a peak of IFN-γ production only on Day 1 after both first and second inoculations. These findings may be associated with the self-replicating properties of the replicon mRNA vaccine following inoculation.
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