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Related Experiment Video

Updated: Jun 16, 2026

An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children

An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children

Published on: October 4, 2018

Selective Serotonin Reuptake Inhibitors for Children with Autism Spectrum Disorder: A Systematic Review and

Elisabetta Trinari¹, Noella Juliana Noronha², Davide Papola^3,4

¹Department of Pediatrics, McMaster University, Hamilton, ON, Canada.

Clinical Medicine Insights. Pediatrics

|June 15, 2026

Summary

This summary is machine-generated.

Selective Serotonin Reuptake Inhibitors (SSRIs) show no clear benefit for children with Autism Spectrum Disorder (ASD). Careful consideration of risks versus benefits is advised due to limited evidence and potential side effects.

Keywords:

GRADE method SSRI autism pharmacology

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Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

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Last Updated: Jun 16, 2026

An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children

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Published on: October 4, 2018

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

Area of Science:

Pediatric Neurology
Psychopharmacology
Autism Spectrum Disorder Research

Background:

Efficacy and safety of Selective Serotonin Reuptake Inhibitors (SSRIs) for Autism Spectrum Disorder (ASD) symptoms and comorbidities remain uncertain.
Systematic review and meta-analyses were conducted to evaluate SSRI efficacy and safety in pediatric ASD populations.

Purpose of the Study:

To determine the efficacy and safety of SSRIs in children diagnosed with ASD.
To assess the impact of SSRIs on clinically relevant outcomes in pediatric ASD.

Main Methods:

Systematic literature search across seven databases for randomized controlled trials (RCTs) comparing SSRIs to placebo in children with ASD.
Independent data extraction, risk of bias assessment, and certainty of evidence rating using the GRADE method by two authors.

Main Results:

Seven RCTs involving 606 participants were analyzed.
Evidence regarding SSRI effects on restricted repetitive behaviors and anxiety symptoms in ASD is very uncertain.
Low certainty evidence suggests minimal to no effect on obsessive-compulsive symptoms and disruptive behaviors.
Moderate certainty evidence indicates little to no difference in global functioning with a slight increase in adverse events.
No studies evaluated SSRI effects on depressive symptoms in this population.

Conclusions:

The limited number of studies highlights the need for further research in pediatric ASD populations.
Current evidence does not support the use of SSRIs for children with ASD.
Individual risk-benefit assessments are crucial pending more robust evidence.