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04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

Repeat CRP measurements and incident myocardial infarction

Daniel Weiner1,2,3, Buu Truong2,3,4, Satoshi Koyama2,3,4

  • 1Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

American Journal of Preventive Cardiology
|June 15, 2026
PubMed

Insights

Persistently elevated C-reactive protein (CRP) indicates a higher risk of myocardial infarction. Repeatedly measuring inflammatory markers like CRP is crucial for accurate cardiovascular risk assessment.

Area of Science:

  • Cardiovascular Disease Research
  • Inflammation Biomarkers
  • Public Health

Background:

  • Inflammation is a known risk factor for cardiovascular disease (CVD).
  • Understanding the stability of inflammatory markers and their association with myocardial infarction (MI) is critical for risk stratification.
  • C-reactive protein (CRP) is a well-established marker of inflammation.

Purpose of the Study:

  • To assess the stability of C-reactive protein (CRP) levels over repeated measurements.
  • To investigate the association between patterns of repeated CRP measurements and the incidence of first-time myocardial infarction (MI).

Main Methods:

  • Analysis of CRP levels in 14,960 UK Biobank participants without diagnosed inflammatory conditions.
  • Utilizing Cox proportional hazards models to estimate the association between baseline/repeat CRP and incident MI.
  • Examining CRP stability and correlation across a median follow-up interval of 4.4 years.

Main Results:

  • Baseline and repeat CRP measurements showed significant correlation (Spearman rho 0.64).
  • Persistently elevated CRP (at both baseline and repeat) was significantly associated with increased risk of first-time myocardial infarction (HR = 1.66).
  • Elevated CRP at only one time point was not significantly associated with incident MI.

Conclusions:

  • Persistently elevated CRP levels are a significant predictor of incident first-time myocardial infarction.
  • Repeated measurement of inflammatory markers, such as CRP, is essential for refining cardiovascular risk stratification.
  • These findings underscore the clinical utility of monitoring inflammation over time for CVD prevention.
Abstract

Keywords:
BiomarkersCADCRPInflammationPrimary prevention

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