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A role for nucleolin in functional improvement in stroke
Samuel P Bridges1, Mary Hovanesyan1, Srbui Azarapetian1
1Department of Neurology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.
Abstract:
Stroke remains a global health concern and a leading cause of adult-onset disability due to limited intrinsic repair capability. Here, we identify nucleolin as a targetable regulator of the repair programs activated following ischemic injury. Through neuron-specific subcellular targeting of axonal nucleolin in the post-stroke recovery period, we see enhanced axonal sprouting and accelerated functional recovery following motor cortex stroke. These findings demonstrate that interference in localized nucleolin functions following cortical stroke is a viable strategy to enhance functional recovery.
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