Related Experiment Video
Updated: Jun 16, 2026

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
Published on: February 4, 2021
The association between time-weighted cumulative life's essential 8 and aortic valve calcification
Man Gui1, Shouling Wu2, Tonghaoyu Wang3
1School of Nursing and Rehabilitation, North China University of Science and Technology, Tangshan, Hebei, China.
Objective:
To examine the association between the time-weighted cumulative Life's Essential 8 (TWC-LE8) score and aortic valve calcification (AVC).
Methods:
This analysis included 15,321 adults (mean age, 63.79 years; 76.44% men) from the Kailuan cohort who completed four health examinations between 2006 and 2012 and subsequently underwent standardized echocardiography. The TWC-LE8 score (range, 0-100) was used to classify cardiovascular health (CVH) as low (<50), moderate (50-79), or high (≥80). Multivariable logistic regression was used to estimate odds ratios (ORs) for AVC across CVH categories, and restricted cubic spline models were applied to assess the dose-response relationship.
Results:
A total of 2,894 AVC cases were identified. Compared with low CVH, moderate CVH was associated with lower odds of AVC (OR = 0.53, 95% CI: 0.47-0.61), and high CVH was associated with even lower odds of AVC (OR = 0.25, 95% CI: 0.15-0.40). A linear inverse association between TWC-LE8 score and AVC was observed (P for trend < 0.001). Age-stratified analyses showed significant heterogeneity. Among participants aged ≥55 years, high CVH was associated with 74% lower odds of AVC (OR = 0.26, 95% CI: 0.15-0.45), whereas no significant association was observed among those aged <55 years.
Conclusion:
Higher cumulative LE8 scores were strongly associated with lower odds of AVC, particularly among older adults. These findings support an inverse association between long-term cardiovascular health and AVC.
Related Concept Videos
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Aortic Regurgitation I: Introduction
Aortic Regurgitation III: Medical Management
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

