A Randomized Clinical Study Comparing Patient Satisfaction and Clinical Outcomes Associated With Two Nasal Packs Used...

Area of Science:

• Otolaryngology
• Biomaterials Science
• Surgical Innovation

Background:

• Biodegradable nasal packs are crucial for managing postoperative bleeding and ensuring patient comfort after nasal surgery.
• Comparing the efficacy and safety of different biodegradable nasal packing materials is essential for optimizing surgical outcomes.

Purpose of the Study:

• To compare the efficacy, safety, and tolerability of VelNez® versus NasoPore® biodegradable nasal packs.
• Primary objectives include assessing hemorrhage control time and biodegradability of the nasal packs.

Main Methods:

• A prospective, open-label, single-center randomized clinical trial involving 20 patients undergoing nasal surgery.
• Patients were randomized to receive either VelNez® (n=10) or NasoPore® (n=10) nasal packs.
• Primary endpoints: hemorrhage control time and nasal pack fragmentation at seven days; secondary endpoints: patient comfort, pain, endoscopic findings, and adverse events.

Main Results:

• VelNez® demonstrated significantly faster hemorrhage control (2.6 min vs. 3.8 min; p=0.033) and superior biodegradability with less residue (p<0.01) compared to NasoPore®.
• Patients using VelNez® reported lower pain scores (p<0.05), less nasal obstruction, and reduced discharge.
• VelNez® group showed less postoperative edema on endoscopic examination (p=0.019); no significant infections or adverse reactions were noted.

Conclusions:

• VelNez® nasal pack is superior to NasoPore® in terms of hemorrhage control, biodegradability, and patient comfort following nasal surgery.
• The use of VelNez® may enhance postoperative recovery, minimize patient discomfort, and reduce potential health risks associated with nasal packing.