A Randomized Clinical Study Comparing Patient Satisfaction and Clinical Outcomes Associated With Two Nasal Packs Used...

Objective This study aimed to compare the efficacy, safety, and tolerability of two biodegradable nasal packs VelNez® (Datt Mediproducts Pvt. Ltd., New Delhi, India) and NasoPore® (Polyganics B.V., Groningen, the Netherlands) in patients undergoing nasal surgery, with the primary objective of assessing haemorrhage control time and biodegradability. Methods In this prospective, open-label, single-centre, randomized clinical trial, 20 patients undergoing nasal surgery were randomly assigned to receive either VelNez® (n=10) or NasoPore® (n=10). Primary endpoints were haemorrhage control time and nasal pack fragmentation at seven days post-surgery. Secondary endpoints included patient comfort, pain scores, endoscopic findings, and adverse events. Statistical analyses were conducted using t-tests and chi-squared tests with significance set at p<0.05. Results VelNez® showed significantly faster haemorrhage control (mean 2.6 minutes) compared to NasoPore® (mean 3.8 minutes; p=0.033). Fragmentation analysis revealed VelNez® had significantly less residue after seven days (p<0.01), indicating better biodegradability. Patients treated with VelNez® reported lower pain scores during surgery, discharge, and first follow-up (p<0.05) and experienced less nasal obstruction and discharge. Endoscopic examination showed less postoperative edema in the VelNez® group at seven days (p=0.019). No significant infections, allergic reactions, and fibrosis were observed in either group. Conclusion The VelNez® nasal pack demonstrated improved haemorrhage control, biodegradability, and patient comfort compared to NasoPore® in nasal surgery. Its use may improve postoperative outcomes, reduce patient discomfort, and lower health risks associated with nasal packing, contributing positively to public health by enhancing recovery and reducing complications.