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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Association between the C-reactive protein-triglyceride-glucose index and major adverse cardiovascular events in

Feilong Shao1, Yazhao Sun2, Chunlan Bai2

  • 1Department of General Practice, Huabei Petroleum Administration Bureau General Hospital, Cangzhou, Hebei, China.

Frontiers in Medicine
|June 15, 2026
PubMed

Insights

The C-reactive protein-triglyceride-glucose index (CTI) predicts adverse cardiovascular events after percutaneous coronary intervention (PCI). Higher CTI levels indicate increased risk, highlighting its importance in patient management post-PCI.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Metabolic Syndrome

Background:

  • Inflammation and insulin resistance are key drivers of atherosclerosis.
  • The combined impact of C-reactive protein (CRP) and triglyceride-glucose index (TyG) on major adverse cardiovascular events (MACEs) is not well understood.
  • The novel C-reactive protein-triglyceride-glucose index (CTI) integrates these factors.

Purpose of the Study:

  • To evaluate the association between the CTI and MACEs in patients undergoing percutaneous coronary intervention (PCI).
  • To assess the predictive value of CTI for adverse cardiovascular outcomes following PCI.

Main Methods:

  • Retrospective analysis of 2,610 patients who underwent PCI.
  • Utilized survival analysis, Cox regression, restricted cubic splines (RCS), and ROC curves.
  • Performed subgroup and sensitivity analyses to validate findings.

Main Results:

  • 459 participants experienced MACEs during follow-up.
  • CTI was identified as an independent predictor of adverse outcomes.
  • A non-linear relationship was observed between CTI and the primary endpoint, with good predictive ability demonstrated.

Conclusions:

  • Pre-PCI CTI levels are significantly associated with adverse cardiovascular outcomes.
  • CTI serves as a valuable prognostic marker for patients undergoing PCI.
Abstract

Keywords:
C-reactive protein–triglyceride-glucose indexinflammationinsulin resistancemajor adverse cardiovascular eventspercutaneous coronary intervention

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