Recent advances in characterizing the immune microenvironment and biomarkers of endometrial carcinoma

This study builds upon existing research achievements in bioinformatics to systematically screen a comprehensive set of biomarkers and prognostic models associated with immune infiltration regulation in the tumor microenvironment of endometrial carcinoma. It elucidates the predictive value of these markers and models as well as the oncogenic signaling pathways in which they are involved, thereby providing a theoretical foundation and molecular insights into the characteristics of tumor immune infiltration in endometrial carcinoma. Through a cross-study analysis, five immune-related markers and two gene families consistently reported across multiple investigations were identified. Their clinical prognostic significance was validated, and potential mechanisms underlying their roles in carcinogenesis were proposed. Furthermore, the functional implications of immune infiltrating cells on tumor behavior are summarized, offering valuable guidance for target identification and therapeutic strategy development in future clinical immunopharmacological research.