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CD38+ NK cells: novel players in immunoregulation.

Xiaotian Chang1,2, Kehua Fang3

  • 1Medical School of Qingdao Huanghai University, Qingdao, Shandong, China.

Frontiers in Immunology
|June 15, 2026
PubMed
Summary

CD38+ NK cells play dual roles in immune regulation, impacting diseases like rheumatoid arthritis and colorectal cancer by affecting T cell differentiation and immune surveillance. Their subtypes, CD38+CD16+ and CD38+CD16-, exhibit opposing effects on immune balance.

Keywords:
CD16CD38CD38+ NK cellsNK cellsimmune surveillanceimmune toleranceregulatory T cells (Tregs)tumor-associated macrophages (TAMs)

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