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Published on: January 22, 2013

RPS29 as a potential early diagnostic biomarker for necrotizing enterocolitis: validation from transcriptomic and

Zhe Wang^1,2, Pengjian Zou², Longlong Hou²

¹The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.

Translational Pediatrics

|June 15, 2026

Summary

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Lipopolysaccharide-binding protein as a biomarker in the diagnosis of necrotizing enterocolitis.

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This study identifies RPS29 as a potential biomarker for early necrotizing enterocolitis (NEC) diagnosis. Decreased plasma RPS29 levels accurately detect NEC in neonates, aiding early intervention.

Area of Science:

Neonatal Medicine
Gastroenterology
Biomarker Discovery

Background:

Necrotizing enterocolitis (NEC) is a severe neonatal gastrointestinal disease with challenging early diagnosis.
Ribosomal protein S29 (RPS29) was identified as differentially expressed in NEC.
This study investigates RPS29 as a potential early diagnostic biomarker for NEC.

Purpose of the Study:

To evaluate RPS29 as a biomarker for early NEC detection.
To assess the diagnostic performance of plasma RPS29 levels in NEC neonates.

Main Methods:

Prospective cohort study analyzing plasma proteomics and transcriptomics.
Quantification of plasma RPS29 by ELISA.
Validation in NEC patient tissues and mouse models using immunofluorescence and RT-qPCR.

Keywords:

Necrotizing enterocolitis (NEC)RPS29 diagnostic biomarker inflammation proteomic

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Diagnostic performance assessed by ROC curves.

Main Results:

Plasma RPS29 levels were significantly decreased in NEC infants, particularly in early stages (Bell stage I).
RPS29 demonstrated high diagnostic accuracy (AUCs up to 0.9861 for stage I).
Downregulation of RPS29 mRNA and protein was confirmed in NEC tissues and models.

Conclusions:

Plasma RPS29 protein shows significant potential as an accurate biomarker for early NEC diagnosis.
RPS29 can aid in the timely detection of NEC, facilitating prompt clinical management.