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Mortality Outcome Post-MI after PCI and CABG Interventions
Mina Muayad Alwan Al-Naqdi1, Mohammed Lateef Mohammed Alkhammasi2, Bassam Muayad Alwan Al-Naqdi3
1Al-Mustansiriyah Primary Healthcare Center, Baghdad, Iraq.
Insights
Three-year mortality after myocardial infarction (MI) did not differ significantly between percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). Non-cardiac causes were the leading cause of death in both groups.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiac Surgery
Background:
- Myocardial infarction (MI) remains a leading global cause of death.
- Effective revascularization strategies are crucial for post-MI patient outcomes.
Purpose of the Study:
- To compare three-year mortality outcomes between percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in post-MI patients.
- To identify causes of death in patients undergoing PCI versus CABG.
Main Methods:
- Retrospective cohort study of 6,786 post-MI patients (3,542 PCI, 3,244 CABG) from 2020-2024.
- Kaplan-Meier analysis for unadjusted survival and Cox regression for adjusted three-year all-cause mortality.
- Adjustment for baseline demographic and clinical covariates to mitigate confounding.
Main Results:
- Crude mortality was 7.99% for PCI and 11.19% for CABG.
- Adjusted three-year all-cause mortality hazard was not significantly different between PCI and CABG (aHR = 1.12, p = 0.280).
- Independent predictors of mortality included age, diabetes mellitus, and renal complications; non-cardiovascular causes predominated deaths (50-56%).
Conclusions:
- Adjusted three-year mortality is similar between PCI and CABG post-MI.
- Non-cardiac causes represent the majority of deaths, highlighting broader health factors.
- PCI and CABG remain vital, with patient selection guided by heart-team assessment.
Background And Aim:
Worldwide, heart-related conditions, including myocardial infarction (MI), persist as the leading cause of morbidity and mortality. The aim is to compare three-year mortality outcomes and identify causes of death among post-MI patients who received either percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG).
Methods:
This registry-based retrospective cohort with follow-up study analyzed data from 3,542 PCI and 3,244 CABG patients treated post-MI between 2020 and 2024 in two hospitals in Baghdad. Kaplan-Meier curves (log-rank test) were used for unadjusted comparison. Cox proportional hazards regression was employed to compare three-year all-cause mortality, adjusting for baseline demographic and clinical covariates.
Results:
Baseline characteristics differed significantly, with CABG patients being older and having a higher prevalence of certain risk factors. Crude observed mortality during available follow-up was 7.99% for PCI and 11.19% for CABG; Kaplan-Meier analysis showed significantly different unadjusted survival distributions by log-rank test. However, after adjusting for baseline covariates, there was no significant difference in the hazard of three-year all-cause mortality between patients undergoing CABG and PCI (adjusted hazard ratio [aHR] = 1.12, 95% CI = 0.93-1.35, p = 0.280). Significant independent predictors of mortality included age (aHR = 1.04 per year), diabetes mellitus (aHR = 1.45), and renal complications (aHR = 1.70). Non-cardiovascular causes accounted for the majority of deaths in both groups (56.06% post-PCI, 50.11% post-CABG).
Conclusion:
In this observational cohort, adjusted three-year mortality was not significantly different between PCI and CABG, with non-cardiac causes accounting for the largest proportion of deaths. Due to potential confounding by indication, these findings represent observational associations rather than clinical equivalence. Both remain vital revascularization strategies, with selection guided by individualized heart-team assessment.
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