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Related Concept Videos

Streptococcal Pharyngitis01:27

Streptococcal Pharyngitis

Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased by a...

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Updated: Jun 16, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
06:23

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

Recurrent Cervical Pyogenic Spondylodiscitis Caused by Streptococcus gallolyticus subsp. pasteurianus: A Case Report.

Takeshi Yamashita1, Katsuyuki Yoshida1, Michiko Matsuzawa Adachi1

  • 1Department of Comprehensive Medicine 1, Division of General Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan, jichi.ac.jp.

Case Reports in Infectious Diseases
|June 15, 2026
PubMed
Summary
This summary is machine-generated.

A rare cervical spine infection caused by Streptococcus gallolyticus subsp. pasteurianus relapsed after standard antibiotics. Extended treatment led to remission, suggesting longer antibiotic courses may be needed for complex spinal infections.

Keywords:
Streptococcus gallolyticus subsp. pasteurianuscase reportcervical spondylodiscitispyogenic spondylodiscitisrecurrence

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Last Updated: Jun 16, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
06:23

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

Area of Science:

  • Infectious Diseases
  • Spinal Surgery
  • Microbiology

Background:

  • Pyogenic spondylodiscitis is a rare spinal infection, with cervical spine involvement in 3-10% of cases.
  • Streptococcus gallolyticus subsp. pasteurianus, a gut bacterium, is an uncommon cause of spinal infections.

Purpose of the Study:

  • To report a case of cervical pyogenic spondylodiscitis caused by S. gallolyticus subsp. pasteurianus.
  • To highlight a clinical relapse and the management of this rare infection.

Main Methods:

  • Case report of an 88-year-old male with cervical spondylodiscitis.
  • Diagnosis confirmed by blood cultures and cervical MRI.
  • Treatment involved initial 90-day antibiotic course, followed by extended oral therapy after relapse.

Main Results:

  • The patient experienced a clinical relapse 174 days after initial treatment.
  • Extended antibiotic therapy for 9 months resulted in sustained remission without surgery.
  • This is the first reported case of clinical recurrence for this specific pathogen in spinal infection.

Conclusions:

  • Standard antibiotic durations may be insufficient for complex or relapsing spinal infections caused by S. gallolyticus subsp. pasteurianus.
  • Individualized treatment duration and long-term surveillance are crucial for managing such cases.