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Updated: Jun 16, 2026

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Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts
Published on: March 26, 2015
Prospective MRI-Based Comparison of Graft Maturation After ACL Reconstruction Using Quadriceps Versus Hamstring
Tunay Erden1,2, Muzaffer Ağır3, M Enes Kayaalp4
1Department of Orthopaedics and Traumatology, Istanbul Health and Technology University, Istanbul, Turkey.
Orthopaedic Journal of Sports Medicine
|June 15, 2026
Summary
Quadriceps tendon (QT) and hamstring tendon (HT) autografts show similar graft maturation after anterior cruciate ligament (ACL) reconstruction. Magnetic resonance imaging (MRI) revealed comparable maturation profiles for both graft types at 6 and 12 months post-surgery.
Area of Science:
- Orthopedic Surgery
- Sports Medicine
- Radiology
Background:
- Graft maturation after ACL reconstruction is prolonged and varies, not always correlating with clinical recovery.
- Magnetic resonance imaging (MRI)-based signal intensity ratio (SIR) is a common indirect marker for graft remodeling.
- Limited comparative data exists on MRI-assessed graft maturation between quadriceps tendon (QT) and hamstring tendon (HT) autografts.
Purpose of the Study:
- To compare graft maturation between all-soft tissue QT and HT autografts.
- Utilize quantitative MRI-based SIR at 6 and 12 months post-ACL reconstruction.
- Evaluate maturation in athletes undergoing primary all-inside ACL reconstruction.
Main Methods:
- Prospective cohort study of 76 athletes (39 QT, 37 HT) undergoing primary all-inside ACL reconstruction.
- Standardized rehabilitation protocol and 3.0-T MRI at 6 and 12 months.
- Graft maturation assessed via SIR, with posterior cruciate ligament as reference; interobserver reliability evaluated.
Main Results:
- No significant differences in mean SIR values between QT and HT autografts at 6 and 12 months.
- Both groups showed significant SIR decrease from 6 to 12 months, indicating progressive maturation.
- No difference in the magnitude of SIR change between graft types; excellent interobserver reliability (ICC=0.98).
Conclusions:
- Quantitative MRI (SIR) shows no significant difference in graft maturation between QT and HT autografts at 6 and 12 months post-ACL reconstruction.
- Both graft types exhibit comparable early postoperative maturation profiles on MRI.
- QT autografts are a reliable alternative to HT autografts in athletic populations undergoing ACL reconstruction.
