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The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension
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Trajectories and Influencing Factors of Depression in Patients with H-Type Hypertension-Related Ischemic Stroke: A

Yuying Guo1, Juanjuan Wang1, Peng Zhao2

  • 1Department of Neurology, National Advanced Stroke Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.

Patient Preference and Adherence
|June 15, 2026
PubMed

Insights

This study identified four depression patterns in patients with H-type hypertension-related ischemic stroke. Positive health behaviors predicted better outcomes, while elevated homocysteine and social support were linked to worsening depression.

Area of Science:

  • Neurology
  • Psychiatry
  • Public Health

Background:

  • H-type hypertension-related ischemic stroke poses significant risks for post-stroke depression.
  • Understanding depression trajectories is crucial for effective patient management.

Purpose of the Study:

  • To identify distinct depression trajectory patterns in patients with H-type hypertension-related ischemic stroke.
  • To explore predictors of these depression trajectories using the COM-B framework.

Main Methods:

  • A prospective longitudinal study involving 588 patients.
  • Data collected at six time points over 12 months post-discharge.
  • Growth mixture modeling and logistic regression analyses were employed.

Main Results:

  • Four depression trajectories were identified: Rapid Recovery, Moderate Improvement, Persistent Low-Symptom, and Symptom-Aggravation.
  • Positive health behaviors, first-time stroke, urban residence, and employment were protective.
  • Elevated homocysteine, higher social support, and unemployment were risk factors, particularly for the Symptom-Aggravation group.

Conclusions:

  • Distinct depression trajectories exist in patients with H-type hypertension-related ischemic stroke.
  • Predictors vary across trajectories, highlighting the need for personalized interventions.
  • Findings can guide targeted strategies to improve depression outcomes in this population.
Abstract

Keywords:
COM-B modelH-type hypertensionlongitudinal studypost-ischemic stroke depression

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