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Updated: Jun 16, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
Published on: March 1, 2024
Adverse pregnancy outcomes and risk factors in women with primary Sjögren's syndrome: data from a prospective study
1Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Objective:
This study aimed to describe the pregnancy outcomes in patients with primary Sjögren's syndrome (SjD) and identify risk factors for adverse pregnancy outcomes (APO) in a prospective single center study.
Methods:
We described the outcomes of 114 pregnant women who fulfilled the established criteria for SjD and analyzed the risk factors for adverse outcomes using multiple factors logistic regression.
Results:
The fetal and maternal outcomes in 114 pregnancies were as follows:100 (87.7%) live births, 11(9.6%) miscarriages (first-trimester pregnancy loss), three (2.6%) stillbirths, six (5.3%) cases with intrauterine growth restriction, five (4.1%) preterm deliveries, seven (6.1%) cases with small-for-gestational-age birth weight, and five (4.4%) cases with preeclampsia or eclampsia. Multivariate analysis revealed that age at pregnancy (odds ratio [OR]:1.402, P = 0.016), anti-U1-ribonucleoprotein antibody positivity (OR = 3.562, P = 0.029), and subchorionic hemorrhage (OR = 7.652, P = 0.002) were independent predictors of APO.
Conclusion:
In our cohort, women with subchorionic hemorrhage or anti-U1RNP antibody positivity require close monitoring because these factors are associated with a higher risk of APO.
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