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DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition
Published on: February 9, 2024
DNA Nanotechnology-Enabled Precise Regulation of Nanozymes and Their Applications
Zishuo Liu1, Yuanbo Zhao1, Haoxiang Chen1
1Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, P.R. China.
Research (Washington, D.C.)
|June 15, 2026
Summary
DNA nanotechnology precisely regulates nanozymes, enhancing their catalytic efficiency and specificity for applications in disease therapy, sensing, and environmental monitoring. This approach overcomes limitations of traditional nanozymes, paving the way for clinical translation.
Area of Science:
- Biotechnology
- Nanotechnology
- Materials Science
Background:
- Nanozymes offer advantages over natural enzymes like stability and cost-effectiveness.
- Limitations include insufficient efficiency, specificity, and adaptability for practical applications.
- DNA nanotechnology provides a programmable and biocompatible platform for nanozyme regulation.
Purpose of the Study:
- To review advances in DNA nanotechnology-mediated nanozyme regulation.
- To elucidate the mechanistic basis of six regulatory modes.
- To examine applications and future directions for DNA-nanozyme hybrid systems.
Main Methods:
- Systematic review of recent literature on DNA nanotechnology and nanozymes.
- Analysis of six distinct regulatory mechanisms.
- Summarization of applications in therapy, sensing, and environmental monitoring.
Main Results:
- DNA nanotechnology enables precise control over nanozyme activity and specificity.
- Six regulatory modes were identified and mechanistically explained.
- Hybrid systems show promise in disease treatment, biomedical sensing, and environmental monitoring.
Conclusions:
- DNA nanotechnology significantly enhances nanozyme performance and biocompatibility.
- These hybrid systems offer a promising avenue for advanced theranostics and monitoring.
- Addressing current challenges is crucial for clinical and industrial translation.
