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Related Experiment Video

Updated: Jun 16, 2026

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
09:17

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

Extracellular Vesicle-embedded alginate hydrogel patch for accelerated wound healing.

Won Ho Jang1, Van Dat Bui1,2, Van Hieu Duong1

  • 1School of Chemical Engineering, College of Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.

Materials Today. Bio
|June 15, 2026
PubMed
Summary

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Polymers·2026

This study introduces a novel hydrogel patch loaded with stem cell-derived extracellular vesicles and an antioxidant to improve wound healing. The EGEV-Gel effectively reduces inflammation and oxidative stress, promoting skin tissue regeneration.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing Research

Background:

  • Skin wound healing is hindered by excessive reactive oxygen species (ROS) and pro-inflammatory macrophages.
  • Current treatments often struggle to effectively manage the complex inflammatory and oxidative environment of wounds.

Purpose of the Study:

  • To develop and evaluate an alginate-based hydrogel patch (EGEV-Gel) for enhanced skin wound healing.
  • To investigate the sustained release of human adipose stem cell-derived extracellular vesicles (hASC-EVs) and epigallocatechin gallate (EGCG) for combined regenerative and antioxidant effects.

Main Methods:

  • Development of an alginate hydrogel patch loaded with hASC-EVs and EGCG.
  • In vitro assessment using a transwell system to evaluate effects on macrophage polarization, ROS scavenging, and cell function.
Keywords:
Anti-inflammationControlled releaseEpigallocatechin gallateExtracellular vesiclesHydrogelWound healing

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  • In vivo study on acute wound-induced mice to analyze macrophage population, ROS levels, and histological skin architecture.

    • Main Results:

    • EGEV-Gel suppressed M1 macrophage polarization and scavenged ROS in vitro.
    • The hydrogel restored the function of dermal fibroblasts and endothelial cells under oxidative stress.
    • In vivo, EGEV-Gel significantly reduced M1 macrophages and ROS levels, promoting normalized skin layer thickness and architecture.

    Conclusions:

    • The hASC-EVs/EGCG-loaded hydrogel patch (EGEV-Gel) demonstrates significant therapeutic potential for wound repair.
    • EGEV-Gel effectively modulates the wound inflammatory microenvironment and combats oxidative stress.
    • This engineered hydrogel presents a promising platform for treating cutaneous injuries.