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Related Concept Videos

Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
Adaptability of Cytoskeletal Filaments01:12

Adaptability of Cytoskeletal Filaments

The cytoskeleton is a complex dynamic structure performing varied functions based on cellular requirements. The adaptability of the individual filaments in the cytoskeleton determines their ability to perform various functions within the cell. It can undergo rapid reorganization during processes like cell division or remain stable for several hours as in the interphase. The adaptability of these filaments depends on stringent regulatory mechanisms. The microfilament and microtubules of the...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Polymers02:34

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The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Types of Step-Growth Polymers: Polyesters01:20

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Updated: Jun 16, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
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Published on: October 7, 2016

Bio-Inspired Copper Coordination Bonds Enable Tunable, Viscoelastic, and Cytocompatible Polyhydroxyalkanoates.

Julianna R Koehl1, Abbey E Robinson1, Samantha N MacMillan1

  • 1Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853-1301, United States.

ACS Polymers Au
|June 15, 2026
PubMed
Summary

Researchers developed new dynamic polyhydroxyalkanoate (PHA) biomaterials using copper ions and imidazole side chains for soft tissue repair. These adaptable materials show promise for regenerating various human organs.

Keywords:
biomaterialsdynamic cross-linkingpolyhydroxyalkanoatespostpolymerization modificationsoft tissue

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Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium
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Published on: July 8, 2015

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Last Updated: Jun 16, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
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Published on: October 7, 2016

Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium
13:34

Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium

Published on: July 8, 2015

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Soft tissue repair and regeneration require viscoelastic and processable biomaterials.
  • Dynamic cross-linking offers a method to achieve these material properties.

Purpose of the Study:

  • To synthesize and characterize novel dynamically cross-linked polyhydroxyalkanoate (PHA) copolymers.
  • To investigate the potential of these PHAs for soft tissue engineering applications.

Main Methods:

  • Synthesis of PHA copolymers with imidazole side chains.
  • Introduction of copper-(II) ions to induce dynamic cross-linking.
  • Assessment of material properties by varying copolymer composition and counterion identity.
  • Evaluation of cytocompatibility with human umbilical vein endothelial cells.

Main Results:

  • Copper-(II) ion addition formed dynamically cross-linked PHA materials.
  • Material properties were tunable based on copolymer composition and counterion.
  • The synthesized biomaterials demonstrated cytocompatibility with endothelial cells.
  • Promising degradation profiles were observed for the developed materials.

Conclusions:

  • Dynamically cross-linked PHAs with imidazole side chains offer tunable properties for soft tissue applications.
  • These materials provide a versatile platform for developing biomaterials for diverse organ regeneration needs.
  • The study informs future development of advanced biomaterials for regenerative medicine.