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Safety profile following mRNA-1273 COVID-19 primary vaccination in healthy adults in Indonesia

Bernie Endyarni Medise1,2, Nastiti Kaswandani1,2, Nina Dwi Putri1,2

  • 1National Committee of Adverse Event Following Immunization (NC-AEFI) Indonesia, Jakarta, Indonesia.

Global Epidemiology
|June 15, 2026
PubMed
Abstract

Insights

The mRNA-1273 COVID-19 vaccine demonstrates a favorable safety profile in Indonesia. Post-vaccination reactions were generally mild and transient, with no significant safety concerns identified.

Area of Science:

  • Vaccinology
  • Immunology
  • Public Health

Background:

  • The mRNA-1273 COVID-19 vaccine (Moderna) has been widely administered globally.
  • Assessing vaccine safety and benefit-risk profiles in real-world settings is crucial post-authorization.

Purpose of the Study:

  • To evaluate the safety and benefit-risk profile of the mRNA-1273 vaccine in Indonesia.
  • To assess adverse events following immunization (AEFI) after primary vaccination with mRNA-1273.

Main Methods:

  • Retrospective analytical study design.
  • Data collected via telephone interviews from 1284 subjects in Jakarta, Indonesia.
  • AEFI assessed within 28 days post-vaccination.

Main Results:

  • Common reactions included local pain, erythema, swelling, and fever, primarily occurring within 1-3 days post-vaccination.
  • Local pain was more frequent in females and younger individuals after the second dose.
  • Four serious adverse events (SAEs) were reported and classified as coincidental.

Conclusions:

  • mRNA-1273 COVID-19 vaccination in Indonesia is safe.
  • The vaccine exhibits an acceptable safety profile with manageable adverse events.
Keywords:
AEFISAEVaccine safety

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