Related Experiment Video
Updated: Jun 16, 2026
04:51
Synthesis of Triazole and Tetrazole-Functionalized Zr-Based Metal-Organic Frameworks Through Post-Synthetic Ligand Exchange
Published on: June 23, 2023
Synthetic Strategies of Fused Triazole Frameworks: A Comprehensive Review
Ramana Tamminana1, Akram Mohammed1
1Department of Chemistry, School of Advanced Sciences, VIT-AP University, Inavolu, Beside AP Secretariat, Amaravati, Near Vijayawada, Andhra Pradesh 522241, India.
ACS Omega
|June 15, 2026
Summary
Fused triazoles, nitrogen-rich heterocycles, offer diverse biological activities and applications. Recent synthetic advances enable efficient construction of these valuable scaffolds for drug discovery and materials science.
Area of Science:
- Organic Chemistry
- Medicinal Chemistry
- Materials Science
Background:
- Fused triazoles are nitrogen-rich heterocyclic compounds with unique electronic and structural properties.
- Their integration with aromatic or heteroaromatic systems leads to significant chemical versatility.
- These scaffolds are pivotal in various scientific domains, including pharmaceuticals and materials.
Purpose of the Study:
- To review recent advancements in the synthetic methodologies for constructing fused triazoles.
- To summarize the diverse biological activities and applications of fused triazoles.
- To highlight emerging uses in catalysis and materials science.
Main Methods:
- Azide-alkyne cycloadditions
- Hydrazine- and hydrazide-based cyclizations
- Thiourea-mediated transformations and annulation approaches
Main Results:
- Efficient synthetic strategies for fused triazoles have been developed, detailing mechanistic features and catalytic systems.
- A wide spectrum of biological activities, including antimicrobial, anticancer, anti-inflammatory, and antiviral effects, has been identified.
- Emerging applications in catalysis, energetic materials, and functional materials are demonstrated.
Conclusions:
- Fused triazoles are versatile scaffolds with significant relevance in drug discovery due to their broad biological activities.
- Recent synthetic innovations provide efficient access to these compounds.
- Their utility extends to advanced applications in catalysis and materials science, underscoring their broad importance.
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