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Development of a Rapid-Acting Oxidized Regenerated Cellulose-Based Powder for Hemostatic Applications
Hyung Hwan Kim1, Joo Hang Lee1, Jeong Eun Park1
1R&D Center, Samyang Biopharm Corp., 295 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13488, Republic of Korea.
ACS Omega
|June 15, 2026
Summary
A novel hemostatic powder, Daedeok plant medical devices surgiguard powder (DMSP), effectively controls bleeding by rapidly absorbing water to promote clot formation. DMSP demonstrates superior hemostatic efficacy and mechanical strength compared to existing products.
Area of Science:
- Biomaterials Science
- Surgical Innovation
- Hemostasis Research
Background:
- Local hemostasis is crucial for controlling intraoperative bleeding, especially in complex surgical scenarios.
- Powder-type hemostatic agents offer advantages in delivery and application for extensive or difficult-to-reach bleeding sites.
- Current hemostatic powders face limitations including insufficient efficacy and slow clot formation.
Purpose of the Study:
- To develop and evaluate DMSP (Daedeok plant medical devices surgiguard powder), a novel powder-type hemostatic agent.
- To assess the hemostatic efficacy, clot-forming capacity, and mechanical properties of DMSP.
- To compare DMSP's performance against commercially available hemostatic products.
Main Methods:
- Development of DMSP, a porous powder agent composed of oxidized regenerated cellulose (ORC) and carboxymethyl cellulose (CMC).
- In vitro assessment of clot-forming capacity and mechanical strength.
- Thromboelastography (TEG) analysis to evaluate coagulation kinetics.
- Comparative analysis against existing commercial hemostatic agents.
Main Results:
- DMSP demonstrated excellent clot-forming capacity and mechanical strength.
- TEG analysis showed DMSP significantly reduced coagulation time and increased clot firmness.
- DMSP exhibited a stronger hemostatic effect compared to commercially available products.
- The agent effectively promotes platelet aggregation and concentrates coagulation factors via rapid water absorption.
Conclusions:
- DMSP represents a promising next-generation hemostatic solution with enhanced efficacy.
- The novel powder addresses limitations of current products, such as delayed hemostasis and slow clot formation.
- DMSP shows significant potential for clinical application in surgical procedures requiring robust bleeding control.
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