Related Experiment Video
Updated: Jun 16, 2026
Evaluation of the Effectiveness of Longitudinal Incision for Endoscopic Submucosal Excavation of Gastric Subepithelial Lesions
Published on: April 28, 2026
Assessing the effectiveness of endoscopic submucosal dissection for hypopharyngeal lesions- a comprehensive
Changen Liu1, Qiang Zhang2, Yaohui Wang3
1Department of Gastroenterology and Hepatology, Central Hospital, Tianjin University /Tianjin Third Central Hospital, Tianjin Institute of Geriatrics, Tianjin Third Central Hospital Branch, Tianjin, China.
Background:
Superficial hypopharyngeal carcinoma typically presents with no obvious clinical manifestations but poses significant management challenges due to its unique anatomical location and potential aggressiveness.
Objective:
To evaluate the clinical efficacy and safety of endoscopic submucosal dissection (ESD) in the treatment of superficial hypopharyngeal carcinoma.
Methods:
We retrospectively analyzed the clinical data of 11 patients with 13 superficial hypopharyngeal carcinomas who underwent ESD at the Gastrointestinal Endoscopy Center of Jiangsu Provincial Hospital of Traditional Chinese Medicine from November 2022 to November 2023.
Results:
All 11 patients were male, with 13 lesions located as follows: left pyriform fossa (53.8%), right pyriform fossa (23.1%), posterior hypopharyngeal wall (15.4%), and posterior cricoid region (7.7%). The average lesion diameter was 1.79 cm (range: 0.1-3.9 cm). The procedure took an average of 34 minutes (range: 10-90 minutes). Intraoperatively, subcutaneous cervicothoracic emphysema occurred in 1 patient (7.7%). Postoperatively, 5 patients (38.5%) reported postoperative pain, and 1 patient (7.7%) developed postoperative fever. During follow-up, choking symptoms were noted in 2 cases (18.2%), and hoarseness occurred in 4 cases (36.4%). The average length of hospitalization was 7.3 days (range: 5-10 days). Postoperative pathology revealed intraepithelial high-grade neoplasia in 46.2% of lesions, carcinoma in situ in 7.7%, and invasive carcinoma in 46.2%. One case of squamous cell carcinoma had positive vertical margins, requiring additional radiotherapy and chemotherapy, while the remaining lesions had negative peripheral and basal margins. The mean follow-up period was 17 months (range: 9-25 months), with no recurrence, metastasis, or esophageal inlet stenosis observed in any patient.
Conclusion:
ESD is a safe and effective treatment for superficial hypopharyngeal carcinoma and can be considered a viable option for the minimally invasive treatment of this condition.
Related Concept Videos
01:29Endoscopic Procedures I: Esophagogastroduodenoscopy
During an EGD, the endoscope can be used to:
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.