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A Modular PLUG-IN Photosynthetic Chassis With Tunable Thermal Control for Mammalian Systems.

Qinhua Gan1,2, Zheng Li1, Yunfei Chen1

  • 1Hainan Engineering & Research Center of Marine Bioactives and Bioproducts, School of Marine Biology and Fisheries, Haikou, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 15, 2026
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Summary
This summary is machine-generated.

Engineered microalgae feature a novel thermal-regulated chassis for controlled growth and high-value compound production. This system enhances lipid accumulation and enables easier product extraction, with potential applications in mammalian systems.

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Area of Science:

  • Synthetic Biology
  • Photosynthetic Bioproduction
  • Microalgal Biotechnology

Background:

  • Microalgae are valuable for producing high-value compounds via photosynthesis.
  • Industrial application is limited by the trade-off between growth and metabolic burden (e.g., compound production, cell wall modification).
  • Constitutive genetic engineering often compromises microalgal cultivator fitness.

Purpose of the Study:

  • To develop a versatile, thermally regulated "PLUG-IN" chassis in Nannochloropsis oceanica.
  • To enable programmable control over metabolic output and cell integrity.
  • To overcome limitations in microalgal bioproduction.

Main Methods:

  • Comparative transcriptomics identified heat-inducible promoters (PNoED, PNoUK).
  • Constructed a modular thermal gene-amplification system.
  • Engineered heat-activated expression of AtWRI1 for enhanced lipid accumulation and temperature-dependent silencing of CesA1 for cell wall weakening.

Main Results:

  • Achieved enhanced accumulation of triacylglycerol and eicosapentaenoic acid via heat-activated AtWRI1.
  • Demonstrated rapid cell wall weakening through temperature-dependent CesA1 silencing without impacting growth.
  • Developed strains capable of grind-free lipid recovery and improved intracellular product accessibility by coupling metabolic and cell-wall modules.

Conclusions:

  • Established a "PLUG-IN" chassis for synchronized control of microalgal growth, production, and cell wall reconfiguration.
  • Demonstrated cross-kingdom compatibility, with engineered programs functional in mammalian hosts.
  • Provides a versatile platform for photosynthetic bioproduction and advancing microalgal synthetic biology.