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Related Experiment Video

Updated: Jun 16, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

Left Atrial Appendage Electrical Isolation Reduces Residual Patency After Device Closure in Patients With Persistent

Peng-Cheng Yao1, Mu Chen1, Qun-Shan Wang1

  • 1Department of Cardiology, Xinhua Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China.

Journal of the American Heart Association
|June 15, 2026
PubMed
Summary

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Left atrial appendage electrical isolation (LAAEI) effectively reduces left atrial appendage (LAA) patency after catheter ablation and LAA closure (LAAC) in atrial fibrillation (AF) patients. This strategy improves outcomes by minimizing stroke risk associated with LAA patency.

Area of Science:

  • Cardiology
  • Medical Devices
  • Electrophysiology

Background:

  • Left atrial appendage (LAA) patency post-catheter ablation and LAA closure (LAAC) is crucial for preventing post-procedure stroke in atrial fibrillation (AF) patients.
  • The impact of LAA electrical isolation (LAAEI) on LAA patency following LAAC remains under investigation.
  • This study addresses the unknown effect of LAAEI on LAA patency in AF patients undergoing combined procedures.

Purpose of the Study:

  • To investigate the effect of LAA electrical isolation (LAAEI) on left atrial appendage (LAA) patency.
  • To evaluate LAA patency after combined catheter ablation and LAA closure (LAAC) in patients with atrial fibrillation (AF).

Main Methods:

  • A cohort of patients with persistent AF undergoing combined catheter ablation and LAAC was studied.
Keywords:
atrial fibrillationcardiac computed tomography angiographyleft atrial appendage closureleft atrial appendage electrical isolationperidevice leak

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Last Updated: Jun 16, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Published on: February 26, 2013

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

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  • LAA patency was assessed using cardiac computed tomographic angiography at 3 months post-procedure.
  • Propensity score matching was employed to analyze clinical, echocardiographic, and procedural characteristics.

    • Main Results:

    • In a matched cohort of 469 patients, LAAEI was associated with a significantly lower rate of LAA patency (34.9% vs. 49.6%; P=0.040).
    • LAAEI demonstrated a protective effect against LAA patency (OR, 0.68).
    • Maximum diameter of the LAA orifice was identified as another predictor of contrast leak into the LAA (OR, 1.04; P=0.046).

    Conclusions:

    • Left atrial appendage electrical isolation (LAAEI) is an effective strategy for reducing LAA patency.
    • This finding is significant for patients with persistent AF undergoing combined catheter ablation and LAAC.
    • LAAEI contributes to improved procedural outcomes by reducing LAA patency.